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Timothy Eley Selected Research

8- cyclohexyl- N- ((dimethylamino)sulfonyl)- 1,1a,2,12b- tetrahydro- 11- methoxy- 1a- ((3- methyl- 3,8- diazabicyclo(3.2.1)oct- 8- yl)carbonyl)cycloprop(d)indolo(2,1- a)(2)benzazepine- 5- carboxamide

2/2016Daclatasvir + asunaprevir + beclabuvir ± ribavirin for chronic HCV genotype 1-infected treatment-naive patients.
3/2015Multiplexed LC-MS/MS method for the simultaneous quantitation of three novel hepatitis C antivirals, daclatasvir, asunaprevir, and beclabuvir in human plasma.
3/2015Sensitive and accurate liquid chromatography-tandem mass spectrometry methods for quantitative determination of a novel hepatitis C NS5B inhibitor BMS-791325 and its active metabolite in human plasma and urine.
6/2014Randomized, placebo-controlled, single-ascending-dose study of BMS-791325, a hepatitis C virus (HCV) NS5B polymerase inhibitor, in HCV genotype 1 infection.
2/2014Efficacy of an interferon- and ribavirin-free regimen of daclatasvir, asunaprevir, and BMS-791325 in treatment-naive patients with HCV genotype 1 infection.

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Timothy Eley Research Topics

Disease

18Infections
12/2022 - 01/2012
11Chronic Hepatitis C
01/2018 - 01/2012
4Diarrhea
01/2018 - 04/2012
3Fibrosis (Cirrhosis)
06/2018 - 02/2014
3Virus Diseases (Viral Diseases)
01/2018 - 01/2016
3Hepatitis C
03/2015 - 01/2012
3Headache (Headaches)
06/2014 - 04/2012
2Breast Neoplasms (Breast Cancer)
01/2018 - 11/2016
2Nasopharyngitis
06/2014 - 04/2013
2Hyperbilirubinemia
10/2013 - 04/2013
1Hepatitis B
12/2022
1Body Weight (Weight, Body)
10/2017
1Fever (Fevers)
06/2014
1Neonatal Hyperbilirubinemia
10/2013
1BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
06/2009

Drug/Important Bio-Agent (IBA)

12asunaprevirIBA
06/2018 - 04/2012
11Antiviral Agents (Antivirals)IBA
12/2022 - 01/2012
11Ribavirin (Virazole)FDA LinkGeneric
11/2016 - 01/2012
9daclatasvirIBA
01/2018 - 04/2013
8Protease Inhibitors (Protease Inhibitor)IBA
02/2016 - 04/2012
7InterferonsIBA
02/2016 - 04/2012
58- cyclohexyl- N- ((dimethylamino)sulfonyl)- 1,1a,2,12b- tetrahydro- 11- methoxy- 1a- ((3- methyl- 3,8- diazabicyclo(3.2.1)oct- 8- yl)carbonyl)cycloprop(d)indolo(2,1- a)(2)benzazepine- 5- carboxamideIBA
02/2016 - 02/2014
4RNA (Ribonucleic Acid)IBA
03/2014 - 01/2012
3Peptides (Polypeptides)IBA
03/2018 - 11/2016
3Member 1 Subfamily B ATP Binding Cassette TransporterIBA
03/2018 - 11/2016
2Aspartate Aminotransferases (Aspartate Transaminase)IBA
06/2018 - 06/2014
2AnionsIBA
03/2018 - 11/2016
2Proteins (Proteins, Gene)FDA Link
01/2018 - 11/2016
2Alanine Transaminase (SGPT)IBA
10/2017 - 06/2014
2N- (3- amino- 1- (cyclobutylmethyl)- 2,3- dioxopropyl)- 3- (2- ((((1,1- dimethylethyl)amino)carbonyl)amino)- 3,3- dimethyl- 1- oxobutyl)- 6,6- dimethyl- 3- azabicyclo(3.1.0)hexan- 2- carboxamideIBA
02/2014 - 01/2014
2telaprevirIBA
02/2014 - 01/2014
1Pravastatin (Pravachol)FDA LinkGeneric
03/2018
1Caffeine (No Doz)FDA LinkGeneric
03/2018
1Digoxin (Digitek)FDA LinkGeneric
03/2018
1Flurbiprofen (Froben)FDA LinkGeneric
03/2018
1montelukast (Singulair)FDA Link
03/2018
1Metoprolol (Toprol-XL)FDA LinkGeneric
03/2018
1Midazolam (Versed)FDA LinkGeneric
03/2018
1Omeprazole (Prilosec)FDA LinkGeneric
03/2018
1Cytochrome P-450 CYP1A2 (CYP1A2)IBA
03/2018
1Cytochrome P-450 CYP2D6 (CYP2D6)IBA
03/2018
1Cytochrome P-450 CYP3AIBA
03/2018
1Cytochrome P-450 CYP2C8IBA
03/2018
1Cytochrome P-450 CYP2C9IBA
03/2018
1Cytochrome P-450 CYP2C19IBA
03/2018
1Organic Cation Transporter 1IBA
01/2018
1AmylasesFDA Link
01/2018
1Rosuvastatin Calcium (Crestor)FDA Link
01/2018
1CreatinineIBA
10/2017
1Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
11/2016
1InterleukinsIBA
02/2014
1NucleosidesIBA
02/2014
1SofosbuvirIBA
01/2014
1Atazanavir Sulfate (Reyataz)FDA Link
10/2013
1Transaminases (Aminotransferases)IBA
04/2013
1Dasatinib (BMS 354825)FDA Link
06/2009
1Tyrosine Kinase InhibitorsIBA
06/2009

Therapy/Procedure

5Therapeutics
02/2016 - 01/2012